Emergence of a Novel Binary Toxin–Positive Strain of Clostridium difficile Associated With Severe Diarrhea That Was Not Ribotype 027 and 078 in China
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چکیده
منابع مشابه
Emergence of Clostridium difficile Ribotype 027 in Korea
BACKGROUND Clostridium difficile infection (CDI) has markedly risen and is associated with hypervirulent ribotype 027 outbreaks in North America and Europe since 2003. The aims of this study were to determine the prevalence of ribotype 027 among C. difficile isolates in Korea, to characterize the ribotype 027 isolates, and to determine the clinical severity of CDI in patients infected with thes...
متن کاملEmergence of a ribotype 244 strain of Clostridium difficile associated with severe disease and related to the epidemic ribotype 027 strain.
BACKGROUND We identified 12 patients with Clostridium difficile infection between July 2011 and March 2012 from whom an unusual C. difficile strain was isolated. This strain had a single-nucleotide deletion of the tcdC gene at position 117 and binary toxin genes, which are characteristic of the hypervirulent ribotype (RT) 027 strain. METHODS A retrospective cohort study of 12 patients infecte...
متن کاملEmergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078.
BACKGROUND Since 2005, an increase in the prevalence of Clostridium difficile infection (CDI) due to polymerase chain reaction ribotype 078 has been noticed in The Netherlands. This strain has also been identified as the predominant strain in pigs and calves. METHODS CDI caused by type 078 was studied in relation to CDI caused by the hypervirulent type 027 and by types other than 027 and 078....
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was found to be slightly different from other HEVs and included a putative ORF (ORF4) of 552 nt that overlapped with ORF1 (online Technical Appendix Figure). A similar pattern of genome organization was observed for both FRHEVs. Phylogenetic analysis of the complete genomes clearly showed that FRHEV was separated from genotype 1–4 HEVs and clustered with rat HEV (Figure). Similar phylogenetic c...
متن کاملClostridium difficile PCR ribotype 078: an emerging strain in humans and in pigs?
In a recent paper, Keel and colleagues concluded that Clostridium difficile PCR ribotype 078 was the most common PCR ribotype among isolates from swine (83% of 119 isolates) and isolates from calves (94% of 33 isolates) in The United States (1). In contrast, only 1 of 23 human isolates collected from two hospitals belonged to type 078. The recent finding of Songer et al. that type 078 is freque...
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ژورنال
عنوان ژورنال: Infection Control & Hospital Epidemiology
سال: 2015
ISSN: 0899-823X,1559-6834
DOI: 10.1017/ice.2015.120